Moreover, Dnmt3a-mutated/Tet2 wild-type leukemia models, or Dnmt3a-mutant/Tet2 heterozygous models, were of the erythroid phenotype and exhibited hypomethylation and overexpression of genes regulating erythrocyte differentiation and homeostasis, including Gata1, Klf1, and Kit, and hypermethylation and low expression of genes involved in leukocyte activation and differentiation (e.g., Myb, Tnfaip3, Ikzf3, and Cd74). This evidence concerns the gene DNMT3A and leukemia.