Mouse AEL tumors established by CRISPR/Cas9 of HSPCs with Trp53 and Bcor mutations had a gene expression profile recapitulating human AEL tumors with an overexpression of erythroid transcription factors such as Gata1, Gata2, and Klf1 [25]. The gene discussed is KLF1; the disease is acute erythroid leukemia.