In diabetic (db/db) and wild type (WT) mice, cardiomyopathy was induced by subcutaneous infusion of angiotensin II by using an osmotic pump and concomitant SGLT2I (dapagliflozin) administration in drinking water; whether angiotensin II infusion developed cardiac hypertrophy, myocardial fibrosis and inflammation, administration of SGLT2I decreased glucose concentration and attenuated fibrosis and inflammation [48]. Here, AGT is linked to cardiac hypertrophy.