GCG and Hyperglycemia: In this context, glucagon-like peptide-1 agents (GLP-1) are of particular importance; these molecules belong to the family of incretin hormones (gastrointestinal hormones released after nutrient intake with the ability to glucose-dependently augment insulin secretory responses during periods characterized by hyperglycemia), and exert their action through GLP-1R, a G-protein coupled receptor.