Recent data suggested that dapagliflozin improved mitochondrial dynamics (OPA1, DRP1, and MFN2), together with skeletal muscle mitochondrial biogenesis (PGC-1α, NRF1, TFAM, and COX IV), and mitophagy (PGAM5 and PINK1) related protein levels in T2D rats [114]. This evidence concerns the gene OPA1 and type 2 diabetes mellitus.