In addition to TAM-derived EVs, recent work by Tang et al. demonstrated both in vitro and in a TNBC murine experimental model that BC small extracellular vesicles (sEVs) carrying miR-106b-5p and miR-18a-5p trigger M2 polarization and PD-L1 expression in macrophages [157]. Here, CD274 is linked to breast cancer.