PCSK9 and atherosclerosis: Even more striking is the observation that double knockout mice for both Ampkα subunits in myeloid cells showed no significant differences in myelopoiesis, plaque size, number of CD68+ lesional cells, or circulating lipids when atherosclerosis was induced by proprotein convertase subtilisin/kexin 9-AAV (PCSK9-AAV) injection [58].