Meta-analysis performed by Z.M Tang et al. proves ANXA1 antibodies are a prominent tool to diagnose lung cancer in all stages, although individual tumor-associated autoantibodies (TAAbs) like ANXA1 showed low diagnostic sensitivity and the combination of multiplex autoantibodies ANXA1 alongside p53, NY-ESO-1, CAGE, GBU4-5, SOX2 offered relatively high sensitivity [89]. This evidence concerns the gene ANXA1 and lung cancer.