The strong relationship between ANXA1 and cancers was investigated by D. Zhu et al. ANXA1 expression correlated to a significant grade in OSCC patients; lower ANXA1 expression was correlated with a poorer differentiation grade; ANXA1 overexpression reduced the cell proliferation while its down-regulation increased proliferation of HB96 cells [90]. The gene discussed is ANXA1; the disease is cancer.