SNCA and cutaneous melanoma: α-synuclein controls the aggregation properties of the protein PMEL17 (melanocytic-specific glycoprotein, a functional amyloid protein), which serves as scaffolding for melanin synthesis in human and skin melanoma cell lines [68]; in dopaminergic neurons, α-synuclein overexpression has neurotoxic effects [69] and causes neuromelanin accumulation [70].