Importantly, we showed previously that EP exerts comparable immunomodulatory effects to dimethyl fumarate (DMF) [4], a well-known Nrf2 activator, and the principle pharmaceutical active ingredient of Tecfidera and Skilarence, i.e., drugs for the autoimmune diseases of multiple sclerosis and psoriasis, respectively. This evidence concerns the gene NFE2L2 and multiple sclerosis.