DNAH8 and colorectal carcinoma: In this study, FoF1–ATPase activity (Figure 4) and CRC (Figure 5) were reduced early in the liver mitochondria of CDAHFD-fed mice, suggesting that some structural changes that alter the activity of FoF1–ATPase may have resulted in increased sensitivity to PTP opening, and the mitochondrial dysfunction caused by PT may contribute to the progression of MASH pathology.