DNAH8 and metabolic dysfunction-associated steatohepatitis: Previously, Yang et al. used a mouse model of fatty liver fed on MCDD [12] and showed an increased production of reactive oxygen species (ROS) in the liver as the pathogenesis of MASH progressed; this suggests that ROS-induced FoF1–ATPase protein denaturation and oxidative modification may be involved in the decrease in FoF1–ATPase activity.