This prolonged immune response, mediated by various cells and molecules, such as macrophages, lymphocytes, and proinflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β, not only promotes tumor progression but also modifies the tumor microenvironment (TME) in several ways. The gene discussed is IL6; the disease is neoplasm.