Among the positive effects, CD8+ T lymphocyte activation is observed because hypoxia can induce surface molecule expression on tumor cells (MHC molecules, ligands for PD-1 and CTLA-4 checkpoint receptors, MICA/B, and HSP70), and some CD8+ T lymphocytes undergo metabolic adaptation using alternative metabolic pathways to adapt to hypoxia, such as fatty acid beta-oxidation, glutamate metabolism, and autophagy. The gene discussed is CD8A; the disease is neoplasm.