Since the results in mock-infected cells suggested the activation of a senescence-like pathway in CFTR-modified cells, and previously published data highlighted a low impact of SARS-CoV-2 on these cells [31,32,49,50,65], we aimed to analyze a possible interaction between senescence pathways, CFTR expression/function, and SARS-CoV-2 infection. The gene discussed is CFTR; the disease is severe acute respiratory syndrome.