A number of studies in cell and animal models of PD have found that HDAC inhibitors such as sodium butyrate and valproic acid (both increasing acetylation) can be neuroprotective, reduce α-synuclein levels, increase autophagy, restore striatal dopamine levels and attenuate motor and non-motor changes [187,188,189,190,191,192,193,194,195,196,197,198]. Here, SNCA is linked to Parkinson disease.