Midbrain:Increased acetylation of H2AK5, H2BK15, H3K9 and H4K5 (in 2–3 PD individuals)Downregulation of HDAC1, HDAC2, HDAC4, HDAC6 and SirT1Higher proportion of acetylated midbrain dopaminergic neuronsCerebral cortex: Increased acetylation (H2AK5, H2BK15, H3K9 and H4K5) in 1 PD individual onlyCerebellar cortex: Increased acetylation of H2BK15. This evidence concerns the gene HDAC2 and Parkinson disease.