In a pan-cancer analysis of NLRP3 inflammasome methylation, it was found that in sporadic CRC, seven NLRP3 inflammasome-related genes (i.e., CARD8, ATAT1, CD36, NLRC3, NLRP3, PSTPIP1, and TXNIP) showed altered DNA methylation statuses. This evidence concerns the gene NLRP3 and cancer.