STAG1 and neoplasm: Data from the Sa1/N syngeneic mouse model presented here support the hypotheses that (1) antibody-mediated modulation of VSIG4 can lead to repolarization of macrophages in vivo from an M2-like to a more M1-like phenotype, and (2) repolarization of macrophages leads to a pro-inflammatory shift in the immune profile within the tumor microenvironment, resulting in reduction in tumor growth.