Next, a gene set variation analysis (GSVA) of publicly available gene sets associated with AD (MADAD) [27], cardiovascular diseases [28,29,30], the immune system [29,31] and type 1 and type 2 keratinocyte response genes [32] was performed, identifying further differences between the low and high IFNG AD subtypes, including in the analysis of lesional and non-lesional skin. Here, IFNG is linked to Alzheimer disease.