IFNG and Alzheimer disease: In contrast, the high IFNG group (PC1 = 20.25%, PC2 = 16.47%) showed a larger separation between the transcriptomes of lesional and non-lesional skin compared to the low IFNG group (PC1 = 16.20%, PC2 = 12.77%) (Figure 3B,C), indicating a stronger alteration of unaffected skin in extrinsic AD skin.