As expected, the established gene signature for AD (meta-analysis-derived atopic dermatitis (MADAD)) was significantly enriched in the lesional skin biopsies of both the high (p = 0.0005) and low (p = 0.0004) IFNG groups, with a tendency towards greater enrichment in the high IFNG group (Figure 5A). Here, IFNG is linked to Alzheimer disease.