Again, 98% of the 100 genes were regulated in opposite directions (Figure 6C,D right), including STAT1 (Dupi DOWN, high IFNG group UP) and CXCR4 (Dupi DOWN, high IFNG group UP) Despite the regulation of AD-related driver genes, a large number of DEGs were not included in the dupilumab response gene signature for both the low (70.4%) and high (72.2%) IFNG AD groups (Figure 6C). Here, CXCR4 is linked to Alzheimer disease.