Interestingly, within the genes exclusively regulated in the high IFNG AD group (507 genes), IFNG response genes such as GATA3, GBP5, GBP1, GZMA, IFNG, IL32, STAT4, TNF, TRPV2 and ZBP1 were highly upregulated (Supplementary Tables S1 and S2). Here, GBP5 is linked to Alzheimer disease.