Among them, 55 individuals (49 families) with non-syndromic LCA or EOSRD carried recessive variants in CRB1, CEP290, GUCY2D, LCA5, NMNAT1, RDH12, RPGRIP1, SPATA7, or TULP1 or a dominant variant in CRX. The gene discussed is TULP1; the disease is severe early-childhood-onset retinal dystrophy.