Interestingly, certain genes commonly associated with Leber congenital amaurosis/early-onset severe retinal dystrophy (LCA/EOSRD) in Western Europe, such as CEP290 and RPE65, were only minimally (CEP290) or not at all (RPE65) involved in the Chilean cohort. Here, RPE65 is linked to severe early-childhood-onset retinal dystrophy.