GJA1 and major depressive disorder: In a study using an unpredictable chronic mild stress (UCMS)-induced mouse model of depression, miR-221/222 directly bound to the 3′ untranslated regions (3′ UTR) of Cx43 mRNA and downregulated Cx43 protein levels; this could be reversed by genistein treatment, subsequently ameliorating depression-like behaviors in the mice [21].