Our findings highlighted the particular association of the rs208294 SNP of P2RX7, corresponding to a gain of function of P2X7R [19,20,21], with more severe forms of COVID-19, being more frequently found in patients with two or more comorbidities and particularly associated with co-morbidities such as cardiovascular conditions and colorectal cancer. Here, P2RX7 is linked to COVID-19.