P2RX7 and metastatic colorectal cancer: Moreover, P2X7R polymorphisms seem to emerge as ancillary biomarkers of the risk and prognosis of cancers, as heralded by the observations that the C allele of the rs208294 SNP of P2RX7 has been associated with better prognosis in metastatic colorectal cancer [48,49], while the C/T genotype has been identified as a protective factor in other cancer situations, such as acute leukemia [48] or prostate cancer [50].