Figure 6A,B show that, in the same set of experiments, the proportions of CD86 + CD11b + M1 macrophages and CD206 + CD11b + M2 macrophages in BLM-treated TLR7-KO mice were increased compared to those in BLM-treated WT and TLR9-KO mice; however, the differences were not statistically significant. The number of F4/80-positive cells in BLM-treated TLR7-KO mice was significantly higher than in BLM-treated WT mice, and the number of F4/80-positive cells infiltrated in skin tissues was also markedly higher than in BLM-treated WT mice (Figure 6C,D, upper panels). This evidence concerns the gene ITGAM and Bloom syndrome.