MAPT and Alzheimer disease: To test this hypothesis, our investigation delved into the effects of GV1001 on the development and severity of Pg-induced periodontitis, the development and exacerbation of systemic and vascular inflammation and atherosclerosis associated with Pg-induced periodontitis, and the accumulation of AD biomarkers (e.g., Aβ42 and p-Tau) in the brains of mice with Pg-induced periodontitis.