In this study, we evaluated the effect of GV1001 on the development of atherosclerosis and AD-like conditions linked to Pg-induced periodontal disease in ApoE-deficient mice, and we found that GV1001 protected against Pg-induced periodontal disease and associated atherosclerosis and Alzheimer’s disease (AD)-like conditions. The gene discussed is APOE; the disease is atherosclerosis.