Our custom panel assessed the mutational status of 20 key genes within known dysregulated pathways in PCa: AR, BCL2, BCL2L1, MCL1, ATM, BARD1, BRCA1, BRCA2, BRIP1, CDK12, CHEK2, NBN, PALB2, RAD51B, AKT1, MAP3K1, PIK3CA, PTEN, MDM2, and TP53 (Table 2). Here, CDK12 is linked to posterior cortical atrophy.