SMYD4 and neoplasm: In BRCA, SMYD4 expression was also significantly lower in all tumor stages in comparison with normal samples (p < 1 × 10−12, p = 1.11 × 10−16, p < 1 × 10−12, and p = 1.96 × 10−12 for stages 1, 2, 3, and 4, respectively) (Figure 5F).