In this analysis, colon and rectal tumors were evaluated separately, and it was observed that SMYD4 expression in colon adenocarcinoma was significantly lower in stage 2, 3, and 4 tumors (p = 1.04 × 10−3, 5.55 × 10−3, and 1.21 × 10−2, respectively) when compared to normal samples. Here, SMYD4 is linked to colon adenocarcinoma.