Differences between the two cohorts at EOT included psoriasis-related genes SERPINB4 and SERPINB13, which belong to a group of keratinocyte differentiation regulators, IL36G and IL36RN, which are biomarkers for psoriasis lesions and correlate with disease activity [62,63], and AKR1B10 which plays an important role in keratinocyte proliferation [64]. Here, IL36RN is linked to psoriasis.