Additionally, various molecules that participate in the signaling pathway of IL-23R, including but not limited to CARD9, EOMES, IL1R1/R2, IL6R, IL7R, IL12B, IL27, RUNX3, NKX-2, PTGER4, TBX21, and TYK2, have been identified as having an association with Ankylosing Spondylitis [47,48,56]. Here, IL23R is linked to ankylosing spondylitis.