miR-29c reduces the inflammatory response of microglia by modulating the NLRP3 inflammasome [188], miR-17-5p ameliorated NLRP3 inflammasome activation-mediated hypoxic–ischemic brain injury in rat [189], and miR-138-5p overexpression in epileptic neurons inhibits NLRP3 by directly binding with ubiquitin-specific peptidase 47 (USP47), a positive regulator of NLRP3 [190]. The gene discussed is NLRP3; the disease is brain injury.