NLRP3 and temporal lobe epilepsy: Yue and colleagues revealed that the NLRP3 inflammasome components are highly expressed in neurons, microglia, and astrocytes in the epileptogenic zone of patients with temporal lobe epilepsy (TLE), a form of epilepsy associated with hippocampal neuronal atrophy, and in the hippocampi of a mouse model of status epilepticus (SE)-induced by pilocarpine [73].