Significant correlations were observed between serum miR-16 expression levels and Cr (r = −0.473, p = 0.002), GFR (r = −0.466, p = 0.001), Cr ≥ 2 (r = −0.562, p = 0.002), hypercalcemia (r = −0.460, p = 0.003), B2M (r = −0.370, p = 0.021), and CRP (r = −0.356, p = 0.022). The gene discussed is CRP; the disease is hypercalcemia disease.