ICAM-1 is a glycoprotein constitutively present on the surface of various cells, including epithelial and endothelial cells, lymphocytes, and monocytes; an upregulation in response to specific stimuli, such as injury or infection, is mediated by cytokines (TNF-α, IFN-γ) or ROS [52,53]. The gene discussed is TNF; the disease is infection.