However, as shown in Figure 8B, with the multiple and regular or semi-regular unconventional activations of the AβPP-independent iAβ generation pathway, it is probable that the T1 crossing would occur during one of the pulses of the pathway’s activity; in such a case, AD would be triggered purely unconventionally, and the T1 crossing would render the pathway self-sustainable. The gene discussed is APP; the disease is Alzheimer disease.