Figure 10A shows the initial state at the time of administration of an ACH-based drug. The levels of AβPP-derived iAβ have crossed the T1 threshold, the self-sustainable AβPP-independent iAβ production pathway was activated, and AD symptoms have manifested. Figure 10B depicts the evolution of the initial state in the presence of an ACH-based drug (green box). The gene discussed is APP; the disease is Alzheimer disease.