Consistent with this, previous research by Doke et al. demonstrated that CASP9 plays a crucial role in CKD pathogenesis, implicating apoptosis, mitophagy, and inflammation in kidney damage [25], thus highlighting the potential of CASP9 inhibition in preserving kidney function and offering a new avenue for CKD treatment development. The gene discussed is CASP9; the disease is Nephropathy.