FGF5 and chronic kidney disease: The MR analysis highlighted the renoprotective potential of FGF5, with higher plasma FGF5 levels associated with a lower risk of CKD (OR = 0.908), higher eGFRcrea (β = 0.005) and eGFRcys (β = 0.004), and lower BUN levels (β = −0.007) (Table 5).