TNF and Fabry disease: Mean plasmatic TNF-α concentration (Figure 2) was significantly increased in plasma from FD patients compared to healthy controls (6.68 ± 0.67 pg/mL in controls and 12.16 ± 1.47 pg/mL in FD patients: in naïve 11.79 ± 2.98 pg/mL and in ERT-treated 12.41 ± 1.47 pg/mL).