GLA and Fabry disease: Fabry disease (FD, OMIM#301500) is an invalidating multisystemic disorder caused by defects in GLA (Xq22, NC_000023.1, mRNA NM_000169.2), a gene encoding lysosomal α-Galactosidase A (α-GalA, EC 3.2.1.22), which is one of the rate-limiting hydrolases in lipid catabolism β.