FBXW7 and cancer: In the present study, siRNA-mediated CEBPB inhibition did not elicit the up-regulation of FBXW7 in the LNCaP spheroid model (Figure 3B), which is consistent with the findings reported by Balamurugan et al. (2010), who showed that CEBPB did not affect FBXW7 promoter expression in cancer cells [15].