In non-excitable cells, including cancer cells, KCa1.1 activation-induced hyperpolarization increases the electrochemical gradient for Ca2+ through voltage-independent, store-operated Ca2+ channels, resulting in increases in the [Ca2+]i, and KCa1.1 activation also reduces [K+]i, resulting in the modulation of intracellular signaling [1,2]. The gene discussed is KCNMA1; the disease is cancer.