In another study, a derivative of 10-HDA, 4-hydroperoxy-2-decenoic acid ethyl ester (HPO-DAEE), induced the apoptosis of A549 human lung cancer cells by activating the ROS-ERK-p38 and C/EBP homologous protein (CHOP) pathways [234,235]. This evidence concerns the gene DDIT3 and lung carcinoma.