Therefore, the antioxidant, anti-inflammatory, and antisenescence properties of RJ as well as the modulation of cellular senescence by targeting Nrf2 activation can be a promising preventive strategy against cancer and other degenerative diseases (NAFLD, neurodegenerative diseases, aging, heart diseases, and cardiovascular diseases) [58,100,101,102,103]. Here, NFE2L2 is linked to neurodegenerative disease.