The beneficial effects of RJ on cognition and AD-related pathologies have been demonstrated in various models, including copper- and cholesterol-fed rabbits [150], hippocampal neurons exposed to streptozotocin [151] and trimethyltin [154], and double transgenic APP/PS1 mice harboring mutations associated with early-onset AD (chimeric mouse/human APP (Mo/HuAPP695swe) and human presenilin 1 lacking exon 9 (PS1-dE9)) [145]. The gene discussed is APP; the disease is Alzheimer disease.