IGHE and Sepsis: The expression of immunoglobulins IgG and IgE anti-ASNase due to enzyme administration, commonly related to hypersensitivity, was quantified, as well as platelet-activating factor (PAF) and monocyte chemoattractant protein (MCP-4), mediators of several leukocyte functions, inflammation, sepsis and anaphylaxis [18,19].