Leucine-rich repeat containing 15 (LRRC15) was recently identified as expressed on the stromal fibroblasts of many solid tumors including PDAC, and the LRRC15 antibody (ABBV-085 Ab) could preferentially kill cancer cells over LRRC15-positive CAFs while also increasing macrophage infiltration in the TME (Figure 2) [20]. The gene discussed is LRRC15; the disease is cancer.