XRCC2 and thyroid cancer: However, a polygenic risk analysis, taking into account genotype combinations of different DNA repair genes, including RAD52 (CC)/XRCC2 (GG)/XRCC3 (CT + TT) (OR = 2.204; 95% CI = 1.08–4.51; p = 0.029), have indicated positive association where the combined variant RAD52/XRCC2/XRCC3 showed a significant five-fold increase in the risk of thyroid cancer compared to the wild type (OR = 5.04; 95% CI = 1.45–17.58; p = 0.007) [43].