The co-occurrence of three variant alleles of XRCC3 rs861539 and RAD51 rs1801321 was associated with a 2.9-fold higher incidence of primary cancer (adjusted OR = 2.9; 95% CI = 1.1–7.7; p = 0.036), and in the case of the presence of four variant alleles of any gene, up to eight times (adjusted OR = 8.0; 95% CI = 1.8–35.0; p = 0.006) [44]. The gene discussed is RAD51; the disease is cancer.