In a study conducted by Wójcicka et al. among the Polish population, it was found that rs1801516 (Asp1853Asn) polymorphism was not associated with the risk of thyroid cancer but played a role as a risk modifier associated with other genes, such as BRCA1, mitigating the negative impact of the rare BRCA1 variant by 0.78 (p = 0.023) [80]. Here, BRCA1 is linked to thyroid gland carcinoma.