IMPDH2 and central nervous system cancer: To survey the clinical relevance of IMPDH1 and IMPDH2 in glioma, we queried the gene expression data of human glioma samples from TCGA (https://genom-cancer.soe.ucsc.edu) (accessed on 15 June 2016) Gene expression levels were quantified by IlluminaHiSeq (RNA-seq percentile) in 516 LGG and 172 GBM samples or by Affymetrix chips in 529 GBM samples of different transcriptional features.