In leukemia cells, a CRISPR/Cas9 library screen in the presence or absence of niclosamide identified DHODH and the heat-shock protein HspA9 (also known as mitochondrial Hsp70 and mortalin) to be overexpressed in surviving cells, and inhibitors of these targets are expected to generate synergy effects with niclosamide [119]. The gene discussed is DHODH; the disease is leukemia.