Valiño-Rivas et al. [51] showed, in both models of IRI (by unilateral ureteral obstruction) and of CKD (treatment with folic acid), that GDF15 administration attenuates the renal effect of IRI by stimulating expression of Klotho, a nephroprotective factor (for review see [49]), reducing oxidative stress, inflammation, and apoptosis, thereby preserving renal function. Here, GDF15 is linked to chronic kidney disease.