BDNF and astrocytoma (excluding glioblastoma): A comparative investigation of the neuroprotective properties of H. erinaceus-isolated hericenone C and deacylhericenone (hericenone C treated with lipase), published by Shimizu, also demonstrated that the BDNF mRNA expression in human astrocytoma cells (1321N1) and the protection against H2O2-induced oxidative stress were considerably higher in the case of deacylhericenone [75].