Given the importance of fetal hematopoiesis in the development of JMML-like MPNs, the zebrafish Shp2-D61G mutant also serves as a dependable and distinctive model resembling JMML for studying the hematopoietic abnormalities resulting from SHP2 mutations in NS [69]. Here, PTPN11 is linked to juvenile myelomonocytic leukemia.