While Li et al. [19] reported cardiomyocyte hypertrophy, hypertension, and upregulated renin secretion in global VDR knockout mice on a normal diet, we failed to find hypertension, increased renin secretion, or LVH in 3-month-old global VDR knockout mice on a rescue diet, which normalizes mineral homeostasis [20]. This evidence concerns the gene REN and Hypertension.