Hyperferritinemia in sepsis is related to a pro-inflammatory state, with increases in IL-6, IL-18, IFNγ, and sCD163, a decrease in the IL-10/TNFα ratio, and the production of elevated levels of reactive oxygen species (ROS) [24,25], leading to the expression of ferritin as an antioxidative stress response and as an acute-phase reactant [26]. This evidence concerns the gene TNF and isolated hyperferritinemia.