Laron syndrome patient-derived cells display the down-regulation of genes involved in the control of the cell cycle, motility, growth and differentiation (CCNA1, CCND1, SERPINB2, AKT3) and an up-regulation of metabolic genes involved in protection from oxidative and genotoxic insults (UGT2B15, TXNIP), as recently demonstrated by genome-wide profiling of Laron syndrome patients compared to normal controls [58]. The gene discussed is SERPINB2; the disease is Laron syndrome.