AKT1 and acute lymphoblastic leukemia: In B-cell precursor acute lymphoblastic leukemia (BCP-ALL), microarray analyses of BCP-ALL cells treated with IGF1 and IGFBP7, which binds and stabilizes the IGF1R on the surface and extends its response to IGF1 or insulin, promoted the up-regulation of genes involved in cell growth, including PI3K/Akt/mTOR, mTORC1, MYC targets, and metabolism, including oxidative phosphorylation-OXPHOS, adipogenesis, fatty acid metabolism, and glycolysis [64].