Other data demonstrate that insulin-induced PD-L1 expression in pancreatic ductal adenocarcinoma cells and coculture of pancreatic ductal adenocarcinoma cell lines and CD8+ T-cells indicated that insulin promoted tumor cell-mediated suppression of CD8+ T-cells’ proliferation, thereby conferring immune evasion [90]. This evidence concerns the gene CD274 and pancreatic ductal adenocarcinoma.