CD4 and neoplasm: The analysis of the infiltrate in tumors from mice treated with anti-PD-1 antibodies in combination with the IGF1R inhibitor PQ401 showed a significant increase of tumor-infiltrating CD8+, CD4+, natural killer and B cells, a decrease in intra-tumoral Treg cells, increased frequency of interferon-γ-producing T-cells and reduced expression of PD-1 and GITR in CD4+ and CD8+ T-cells.