Combination studies evidenced synergistic effects between the IGF-Trap and fibroblast growth factor receptor (FGFR) inhibitors [132], while other data demonstrated that the IGF-Trap inhibited the growth of pancreatic ductal adenocarcinoma liver metastases by altering the tumor microenvironment [133]. This evidence concerns the gene IGF1 and pancreatic ductal adenocarcinoma.