Based on the MGH-OLINK-COVID-19 dataset, the ADAM-17 substrate z-score was overall (day 0, day 3 and day 7 altogether) higher in patients with severe COVID-19 (OR = 1.45 per SD 95% CI 1.09–1.93, p = 0.01, Figure 1A) adjusting for comorbidities, age, and BMI categories. The gene discussed is ADAM17; the disease is COVID-19.