APP and Alzheimer disease: The Tukey test has been used to evaluate differences found between different groups in order to evaluate the possible efficacy of specific polyphenols or extracts of polyphenol in animal models that include mice that have been induced for AD with aluminum chloride [59,61], with streptozotocin [109], with scopolamine [110], or in transgenic amyloid precursor protein (APP)/PS1 (Tg) mice [111].