These include Cer accumulation, LAMP-2 and NT up-regulation, brain aneurysms, mitochondrial damage (cerebral cortex, heart, kidney, liver), cellular infiltrates (heart, liver, kidney), increased Bowman’s space, interstitial hemorrhage between proximal tubules (kidney), and dilated rough ER (liver) [47]. Here, CBLN1 is linked to brain aneurysm.