ECM components of tumor tissues revealed no difference from normal mucosa, whereas their levels were generally displayed as increased ECM proteins (LOX, LAMB3, ADAMTSL1, and FBN2) and decreased basement membrane components (COL4A5, COL4A6, COL28A1, NID1, and LAMA5) that were closely related to tumor angiogenesis, invasion, and metastasis, which were closely related to OS of GC patients [50]. This evidence concerns the gene COL28A1 and neoplasm.