This dual modulatory effect was mirrored in tumor-infiltrating NKT cells, where a decrease in the percentage of PD-1+, FoxP3+, IL-10+, and KLRG1 MFI+ expression was accompanied by an upregulated expression of the activating receptors NKp46 and FasL (Figure 3F–K). The gene discussed is KLRG1; the disease is neoplasm.