Furthermore, tumor-infiltrating leukocyte analysis revealed a lower percentage of FoxP3+ and IL-10+ Tregs as well as a decreased percentage of Gr-1+CD11b+CD11c−, NFκB+, and iNOS+CD11b+CD11c−Gr-1+ MDSCs in metformin-treated mice (Figure 5D–H), aligning with Qin et al.’s findings that metformin treatment via NF-κB inhibition suppressed MDSC migration [47]. Here, NOS2 is linked to neoplasm.