Here, we provide evidence that, in addition to already known factors such as PDGF [37] and LOX [36], ADAM12 and rsBSG modulate the extracellular matrix as evidenced by the increased deposits of type 5 collagen in the stroma around the MCF7 tumor, producing increased ADAM12 in a nude mice tumor model system (Figure 5). Here, LOX is linked to neoplasm.