SPINK7 and ulcer disease: Moreover, ECRG2/SPINK7-deficient mice (SPINK7−/−) developed more severe colitis with more extensive ulcers, a higher disease activity index, and more severe body weight loss compared with their wild-type littermates; the loss of ECRG2/SPINK7 also impaired the recovery of colitis after DDS exposure was stopped [36].