TP53 and neoplasm: Recent studies have revealed that the deregulation of GSK3b (glycogen synthase kinase 3 beta) promotes tumor cell survival, proliferation, invasion, and resistance to chemo- and radiation therapy in humans by inhibiting p53 (tumor suppressor protein) and RB (retinoblastoma) tumor suppressors, inducing intracellular NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling, Cyclin D1 (promotes G1/S cell cycle progression) overexpression, and local chronic inflammation [148].